The overexpression of 15-LOX-1 and the inhibition of PPAR beta/delta, likely followed by an increase of 13-HODE production and binding to PPAR gamma, were able to reduce colitis-associated colorectal cancer in mice by reducing the phosphorylated signal transducers and activators of transcription 3 (STAT3) [64], which, when highly expressed in GBM, is associated with a significantly reduced patient survival [34]. Here, STAT3 is linked to colitis.