ALOX5 and glioblastoma: To evaluate the importance of the lipoxygenase and cytochrome P450 components in GBM, the mRNA levels of the following enzymes involved in the metabolism of fatty acids were examined: 5-LOX, LTA4H, LTC4S, FLAP, 12-LOX, CYP4A11 (Cytochrome P450 Family 4 Subfamily A Member 11), 15-LOX-1, and 15-LOX-2.