We showed that Ech could inhibit VEGF-induced HUVEC proliferation with an IC50 value of 103.2 nM and inhibit the migration of human melanoma A375, glioblastoma U373MG, and pancreatic Panc-1 tumor cells with IC50 values of 1.5, 5.7, and 154.5 nM. Here, VEGFA is linked to melanoma.