In this study, p16+ oropharyngeal cancer had a significantly higher proportion of low pathologic T classification (pT1 and -2) than the p16− group (91.0% vs. 68.3%, p = 0.003) and a higher proportion of pathologically identified lymph node metastasis without significance (pN+, 70.1% vs. 48.8% of pN−, p = 0.060). Here, CDKN2A is linked to oropharynx cancer.