When all blood measurements were simultaneously evaluated in a multivariate setting, CD3+CD4+ T cells, CD4+/CD8+ ratio, and CD4+MFI were the only markers selected by the models in all 30 instances of a leave-one-out cross-validation procedure, which highlighted the predictive power of these parameters and indicated that, to some extent, they contribute independently to the prediction of COVID-19 critical evolution. Here, CD4 is linked to COVID-19.