In addition to tumor suppression, p53 has also been demonstrated to be involved in the regulation of many other biological and pathological processes, including anti-infection, immune response, maternal reproduction, development, tissue ischemia/reperfusion injuries, neurodegenerative diseases and aging [2,3,4,26,27,28,29,30,31,32]. The gene discussed is TP53; the disease is neurodegenerative disease.