Further, ~90% of p53 mutations occur in the DNA-binding domain of p53, including several mutational hotspots (e.g., R175, R245, R248, R249, R273 and R282) that account for around one third of p53 mutations in cancers, which impairs the ability of p53 to bind to its target genes to transcriptionally regulate these genes [5,6,7,8,9,12,13]. Here, TP53 is linked to cancer.