However, at the protein level there is a significant increase of in the MFI detection of IKZF3 positive CD27+IgD− switched memory (SwM) B cells and CD27+IgD+ double-positive non-switched memory (NSM) B cells in 10 SLE cases and 10 healthy controls, with moderate increases in the detection of MFI in CD27−IgD− DN B cells and CD27−IgD+ mature naive B cells (naive) in the patients compared with the healthy controls [26]. Here, IKZF3 is linked to systemic lupus erythematosus.