The association at the IKZF3 locus in European SLE is different from that seen in the other autoimmune diseases, where the association is driven by a high frequency (MAF > 40% risk allele): Crohn’s Disease (rs2872507, rs12946510) [17,18]; Rheumatoid Arthritis (rs2872507) [21]; Primary Biliary Cirrhosis (rs8067378) [22]; Ulcerative Colitis (rs12946510, rs2872507) [18,23]; Multiple Sclerosis (rs12946510) [19]; Inflammatory Bowel Disease (rs12946510) [18]; Childhood Asthma (multiple variants) [24] or T1D (rs12453507) [25]. This evidence concerns the gene IKZF3 and autoimmune disease.