IKZF3 and systemic lupus erythematosus: In summary, the LD break-points in both the AA ImmunoChip and AFR 1000G datasets allow us to massively reduce, by >47%, the IKZF3 risk haplotype first identified in the Euro-Canadian SLE GWAS, leading to a risk haplotype covering 101 kb (chr17:37920146-38021117), restricted to the coding region for IKZF3 and carrying only 140 European tag-SNPs.