The importance of this gene family in SLE pathogenesis is evidenced by the associations (Pmeta < 5 × 10−8) for three family members: IKZF1 (Ikaros) (rs2366293-C, rs4917014-T), IKZF3 (Aiolos) (rs2941509-T) and IKZF2 (Helios) (rs6435760-C) [12]. This evidence concerns the gene IKZF1 and systemic lupus erythematosus.