The focus of this manuscript the trans-ancestral fine mapping and epigenetic characterization of the two IKFL1-derived IKZF transcription factors, namely IKZF3 and IKZF1. There is strong evidence to support both IKZF1 and IKZF3 as strong candidates for SLE. The gene discussed is IKZF1; the disease is systemic lupus erythematosus.