A significantly higher mean concentration of ZO-1 was observed in patients >65 years of age compared to younger patients (0.59 vs. 0.48 ng/mL; p = 0.010) and in patients with arterial hypertension compared to patients without the disease (0.63 vs. 0.26 ng/mL; p = 0.026) (Figure 3). The gene discussed is TJP1; the disease is Hypertension.