Of the 223 pathogenic or likely pathogenic variants identified, the most common result was a heterozygous APOB c.10580G > A (p. Arg3527Gln) (n = 16) (Figure 1E), which is associated with familial hypercholesterolemia and found in approximately 0.06% of individuals of European, non-Finnish ancestry (17, 18). This evidence concerns the gene APOB and familial hypercholesterolemia.