There were no significant associations between the ADRB2 A46G polymorphism and hypertension risk under five genetic models: allele genetic model (OR: 1.07, 95% CI: 0.92–1.24, P = .38, Pheterogeneity < .001), homozygote genetic model (OR: 1.16, 95% CI: 0.88–1.52, P = .29, Pheterogeneity < .001), heterozygote genetic model (OR: 1.03, 95% CI: 0.83–1.26, P = .81, Pheterogeneity < .001), dominant genetic model (OR: 1.06, 95% CI: 0.85–1.33, P = .58, Pheterogeneity < .001), and recessive genetic model (OR: 1.14, 95% CI: 1.00–1.30, P = .052, Pheterogeneity = .09) (Table 4). The gene discussed is ADRB2; the disease is Hypertension.