NFKB1 and diabetes mellitus: Through the supplement of probiotics to the animal model, some researchers found that probiotics effectively improved the blood glucose of T2DM animals.[14] In addition, NF-κB can up-regulate pro-inflammatory cytokines and activate JAK/STAT3 signal pathway.[15] Probiotics reducing proinflammatory cytokines by inhibiting NF-κB pathway is also proved to be an effective method for the treatment of diabetes.