The analysis of 371 HCC tumors from TCGA showed a significant inverse correlation between the EZH2 expression levels and major MHC class I antigen presentation molecules, including B2M, HLA-A, HLA-B, HLA-C, and HLA-E (Fig 5A–5E), highlighting a potential regulatory function of EZH2 on antigen presentation in HCC. This evidence concerns the gene HLA-B and hepatocellular carcinoma.