When the expression of EZH2 in HCC specimens from different subgroups of HCC patients in the TCGA database were analyzed, female and older HCC patients showed a significantly higher expression of EZH2 in their liver tissues than in the normal liver tissues (Fig 2A and 2B), the mRNA levels of EZH2 were found to be significantly increased in the higher tumor grades and stages compared to normal tissues (Fig 2C and 2D). This evidence concerns the gene EZH2 and hepatocellular carcinoma.