Amplification and/or overexpression of the ERBB2 gene, which encodes human epidermal growth factor receptor 2 (HER2), is seen in 15–20% of invasive breast cancers [2] as determined using fluorescence in situ hybridization (FISH) or immunohistochemical (IHC) staining of the HER2 [2, 3]. This evidence concerns the gene ERBB2 and invasive breast carcinoma.