MAPT and Alzheimer disease: However, previous studies have shown that synthetic Tau fibrils and AD Tau fibrils, although having unique conformational features and differential potencies in seeding Tau aggregation, are able to induce Tau pathology when injected intracerebrally in WT or transgenic mice, or when introduced into primary neurons (Guo & Lee, 2013; Guo et al, 2016a; Guo et al, 2016b; Gibbons et al, 2017).