MAPT and Alzheimer disease: In AD brains, phosphorylated Tau accumulates first at the noradrenergic locus coeruleus (Braak et al, 2011; Grinberg & Heinsen, 2017), with seeding first detected at entorhinal/limbic areas (Kaufman et al, 2018), before it spreads in a stereotypical manner to interconnected neocortical regions (Jucker & Walker, 2011).