In AD, neuronal phospho‐Tau first appears in the locus coeruleus and in the trans‐entorhinal cortex before it spreads to the hippocampal formation and neocortex, following a predictable pattern (Braak & Braak, 1991; Braak et al, 2011; Jucker & Walker, 2011; Grinberg & Heinsen, 2017; Kaufman et al, 2018). The gene discussed is MAPT; the disease is Alzheimer disease.