In the present study, a signature for BRCA radiotherapy sensitivity prediction was developed based on the expression of six characteristic DEGs, including HOXB13, NKX2-2, ADAMTS20, LOC284930, ACTL8 and LOC101928978, in BRCA tumor samples compared with their paracancerous samples for the first time. This evidence concerns the gene NKX2-2 and neoplasm.