CBS and hyperinsulinemic hypoglycemia, familial, 4: In contrast to CBS deficiency however, re-methylation disorders are also complicated by micro-angiopathy, which may at any age manifest either as chronic glomerular or tubulo-interstitial disease, acute renal failure under the clinical picture of atypical haemolytic-uraemic syndrome, pulmonary arterial hypertension or hydrocephalus (the latter mainly in newborns).