Of note, many ICD inducers induce multiple DAMPs, for example, anthracyclines, radiotherapy, and Hyp‐PDT provoke ICD via inducing the surface exposure of CRT and HSPs, the secretion of ATP and HMGB1, and the release of mtDNA that stimulates the production of type I IFNs (Fig. 2) [2]. This evidence concerns the gene HMGB1 and impulse control disorder.