Obtained results suggested that ACE2 in luminal A subtype was significantly positively correlated with all the major markers like TLRs (TLR4, TLR7, TLR8, and TLR9), NK cells (NCR1, NCAM1, and KLRB1), Neutrophils (CEACAM3, FCGR3B, and FPR1), Monocytes (CSF1R, CD86, and C3AR1), Macrophage (MS4A4A, CD68, and CD163) and Dendritic Cells (ITGAX, FSCN1, and ADAM19) indicating immunological susceptibility of luminal A subtype cancer towards ACE2. Here, TLR8 is linked to cancer.