PD-L1/PD-L2 SVs are associated with upregulation of the NF-κB signaling pathway [28], more common in the non-GCB subtype of DLBCL [26, 28], associated with inferior progression-free survival (PFS) and overall survival (OS), and in the r/r setting tend to respond to anti-PD-1 ICI treatment [28]. This evidence concerns the gene PDCD1 and diffuse large B-cell lymphoma.