CD274 and diffuse large B-cell lymphoma: More importantly, at the transcriptional level, PD-L1/PD-L2 structural variations (SVs) are found in 20-25% of DLBCL [26, 28], while recurrent translocations between PD-L1/PD-L2 and the IGH locus are also detected and considered a genetic mechanism of PD-L1 (but not PD-L2) overexpression [26].