Data generated from genomic studies and observations in unselected patients from clinical studies of ICIs in NHL, mainly of the large B-cell subtype, suggest that lymphomas with a T-cell-inflamed phenotype collectively share common characteristics, including a T-cell immune surveillance infiltrate [29], genomic alterations that drive overexpression of PD-L1 [23, 26–28, 30, 31], and cell-intrinsic NF-κΒ activation [32–34]. Here, CD274 is linked to lymphoma.