BTK and diffuse large B-cell lymphoma: In a similar phase 1b/2 study in patients with r/r DLBCL or FL, the combination of durvalumab plus the BTK inhibitor ibrutinib induced an ORR of 13% in patients with the GCB subtype and 38% with the non-GCB subtype of DLBCL and 12-month PFS of 12.5% in the GCB and 26.7% in the non-GCB subtype [50], results similar to those observed with the single-agent ibrutinib in a similar setting [51].