In the present study, we found that there were negative correlations between ALB and GDF15 (r = −0.775, p < 0.0001) (see Figure 2(d)) and GDF15 and weight changes (r = −0.541, p = 0.0138) (see Figure 2(e)) in cirrhotic patients with PBC. This evidence concerns the gene ALB and primary biliary cholangitis.