We hypothesize that certain differentially expressed circRNAs identified in our analysis (hsa_circRNA_103670, hsa_circRNA_103809, hsa_circRNA_000367, hsa_circRNA_ 102413) may modulate the PI3K/Akt signaling and consequent production of IL-1 beta, CGRP, or other factors leading to migraine development. This evidence concerns the gene IL1B and migraine disorder.