As reported, CDKL1 overexpression could decrease the chemosensitivity of oral squamous cell carcinoma cells to hydroxycamptothecin [11], the reduction of CDKL1 attenuated tumor proliferation and invasion in colorectal cancer [12], inhibited proliferation, and improved apoptosis of GC [13]. This evidence concerns the gene CDKL1 and oral cavity squamous cell carcinoma.