COVID-19 patients hospitalized at intensive care unit (ICU) exhibit augmented levels of inflammatory cytokines and infection biomarkers, such as interleukin (IL)-1B, IL-7, IL-8, IL-9, IL-10, interferon (IFN)-γ, interferon gamma-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)1A, MIP1B, platelet-derived growth factor (PDGF), tumor necrosis factor-alpha (TNFα), and vascular endothelial growth factor (VEGF). This evidence concerns the gene TNF and infection.