Among the identified pathways, the HIF-1 (26, 27) and neurotrophin (28) signaling pathways, whose corresponding target genes were MAPK1, SERPINE1 and CAMK2D for HIF-1 signaling pathways and CDC42, MAPK1, MAP3K3, and CAMK2D for neurotrophin signaling pathways in our analysis, have been implicated in the inflammation pathogenesis of sarcoidosis according to previous studies. Here, SERPINE1 is linked to sarcoidosis.