The HIF-1 signaling pathway was proven to regulate Th1/Th17 mediated inflammation in sarcoidosis (27) and be linked to imbalance of CD4+/CD8+ in BALF and acknowledged negative prognostics (26), consistence with the result that the expression of four miRNA had moderate correlation with the ratio of CD4+/CD8+. This evidence concerns the gene CD8A and sarcoidosis.