Cardiomyocyte-specific deletion of Hoxb13 defers the postnatal window of cardiac regeneration and reactivates cardiomyocyte cell cycle entry in adult heart, whereas double knockouts of Meis1 and Hoxb13 lead to widespread cardiomyocyte mitosis and improved left ventricle systolic function after myocardial infarction (Nguyen et al., 2020). Here, HOXB13 is linked to myocardial infarction.