Indeed, MT1-MMP might direct invadopodia assembly, favoring TKS5 recruitment and formation of mature invadopodia, while MT1-MMP proteolytic activity contributes to invadopodia expansion and collagen remodeling, by promoting matrix pore enlargement to facilitate tumor-cell invasion (Ferrari et al., 2019). Here, SH3PXD2A is linked to neoplasm.