TGFB1 and neoplasm: Similarly, in Extramammary Paget’s disease (EMPD), a major life-threatening skin cancer, TGF-β produced by cancer cells upregulates podoplanin expression in peritumoral basal keratinocytes, mimicking the invasive front of squamous cell carcinoma and supporting tumor cell invasion via invadopodia (Cho et al., 2017).