Similarly, in Extramammary Paget’s disease (EMPD), a major life-threatening skin cancer, TGF-β produced by cancer cells upregulates podoplanin expression in peritumoral basal keratinocytes, mimicking the invasive front of squamous cell carcinoma and supporting tumor cell invasion via invadopodia (Cho et al., 2017). The gene discussed is PDPN; the disease is extramammary Paget disease.