Central to cobblestone lissencephaly hypotheses is post-translational regulation of dystroglycan (coded by DAG1, dystrophin-associated glycoprotein 1), a glycoprotein present in RG basal processes, that acts as an anchor point with the ECM (Booler et al., 2016), being also important for BM structure (Henry and Campbell, 1998). The gene discussed is DAG1; the disease is lissencephaly spectrum disorders.