As shown in Figures 7D,E, the ratio between CD8+ T cells versus Treg cells (R = −0.51, P < 0.0001) as well as the ratio between Th17 cells versus Th2 cells (R = −0.31, P < 0.0001) was negatively correlated with the methylation risk of ccRCC patients. The gene discussed is CD8A; the disease is nonpapillary renal cell carcinoma.