Recent studies reported that PD-L1-deletion significantly increases the number, proliferation (Ki67), and effector function (GzmB) of CD8+ T cells, while decreasing the exhaustion (TIM-3) of CD8+ T cells in the draining lymph node of mice injected with TRAMP-C2 prostate cancer cells (Poggio et al., 2019). Here, CD274 is linked to Familial prostate cancer.