Furthermore, the production of IFN-γ, IL-2, and TNF-α by CD8+ T cells was decreased in the presence of ExoPD-L1 derived from melanoma, breast cancer, NSCLC, and prostate cancer (Chen G. et al., 2018; Yang et al., 2018; Kim et al., 2019; Poggio et al., 2019; Cordonnier et al., 2020). This evidence concerns the gene CD8A and prostate cancer.