However, genetic deletion of PD-L1 in TRAMP-C2 prostate cancer cells, which causes a reduction of both cell-surface PD-L1 and ExoPD-L1, strikingly prevents anti-PD-L1 antibody resistant tumor to grow in mice (Foster et al., 1997; Poggio et al., 2019). This evidence concerns the gene CD274 and prostate carcinoma.