Interaction between astrocyte-derived exosomes that contain neurotrophic induced cargoes such as co-chaperone stress-inducible protein 1 (STI1), and neuronal surface components could also enhance their pathological signaling (Hajj et al., 2013); STI1 also induced glioma through different pathways and is involved in neuronal death and neurodegenerative diseases (Erlich et al., 2007; Landemberger et al., 2018). This evidence concerns the gene STIP1 and central nervous system cancer.