In this context, TNF-α-induced p38 signaling was shown to promote the interaction of transcription factor YY1 and the polycomb repressive complex 2 to induce repressive chromatin structures at target gene promoters (Palacios et al., 2010), while tumor suppressor SALL1 induces p38-dependent NuRD recruitment to promote cancer cell senescence (Ma et al., 2018). Here, TNF is linked to cancer.