Of particular interest, the CCNL1 gene was ranked 4th from a meta-analysis for association with severe diabetic retinopathy (P = 7.1 × 10–7), but was no longer top-ranked for association with diabetic retinopathy when individuals with nephropathy were removed from the case group (Grassi et al., 2011). The gene discussed is CCNL1; the disease is kidney disorder.