CD8 T cells secrete cytokines involved in parasiticidal effects, in particular IFNγ and TNFα (Fischer et al., 2000; Schlüter and Barragan, 2019), and can directly control cyst burdens in the CNS via perforin-mediated cell lysis, although this effect seems to be limited and independent of IFNγ (Denkers et al., 1997; Wang et al., 2004; Suzuki et al., 2010, 2011; Landrith et al., 2015). Here, IFNG is linked to cyst.