Furthermore, while mice lacking either MyD88 or IL12p40 succumb rapidly to infection, mice that lack Myd88 specifically in DCs or macrophage lineages do not, indicating that there are other factors and cytokines that regulate IL12 and IFNγ secretion (Scanga et al., 2002; Hou et al., 2011). The gene discussed is MYD88; the disease is infection.