TRIM22 and periodontitis: The prediction of transcriptome sequencing and the verification assay suggested that LL-37 plays an important role in autophagy and might promote autophagy of keratinocytes by regulating TRIM22 and LAMP3. This study provides scientific clues about the role and potential application of LL-37 in the elimination of P. gingivalis in keratinocytes, and in turn, it can be used to develop methods for the prevention of periodontitis treatment of associated diseases.