FN1 and neoplasm: The dense desmoplasia stroma of PDAC consists of several cellular components (e.g., fibroblasts, stellate cells, immune cells, and pericytes), acellular components (e.g., fibrin, collagen, hyaluronic acid, fibronectin, growth factors, and cytokines), and biophysical components (e.g., low pH, hypoxia, and high tumor IFP) (11).