The level of γ-H2AX had a little increasing following 6 Gy IR treatment alone, whereas both mirin and NU7441 enhanced γ-H2AX recruitment and combination of two inhibitors led to the higher level of γ-H2AX (Figures 6A, B), indicating that inhibiting DSB repair pathways could enhance IR-inducing DSBs in ESCC cells. The gene discussed is H2AX; the disease is esophageal squamous cell carcinoma.