Other genes such as SHFM1, RAD52, RAD51B, and MUS81 were also remarkably amplified in ESCC with the frequency 16.2% (25/154), 12.3% (19/154), 11% (17/154), and 10.4% (16/154), respectively. The gene discussed is RAD51B; the disease is esophageal squamous cell carcinoma.