Subsequently, 12 radiomics features were screened by LASSO method for CXCL8 expression assessment in 99 CRC patients, and the novel model incorporating above 12 features showed good performance in training, testing, and IHC testing cohorts with AUC of 0.829, 0.727, and 0.682, respectively. This evidence concerns the gene CXCL8 and colorectal carcinoma.