Our results demonstrated that NE promoted the invasiveness of glioma cells, while the number of cells that migrated through the matrix glue in the shRNA-CD147 group of LN229 cells decreased by 43.75% and that the shRNA-CD147 group of U87 cells were reduced by 53.57% compared with the control group (P<0.05) (Figure 3B). The gene discussed is BSG; the disease is central nervous system cancer.