CRP and Familial prostate cancer: In contrast, another prospective study including 34,891 men reported that circulating levels of CRP were not associated with risk of prostate cancer [HR (hazard ratio) 0.87, 95% CI 0.65 to 1.16 for CRP concentrations 10–15 mg/L; HR 0.95, 95% CI 0.47 to 1.92 for CRP concentrations 15–25 mg/L; HR 1.35, 95% CI 0.74 to 1.92 for CRP concentrations 25–50 mg/L; and HR 0.90, 95% CI 0.37 to 2.19 for CRP concentrations >50 mg/L, compared with CRP concentrations <10 mg/L as the reference group] (10).