Meanwhile, G-CSF is also an important factor to recruit neutrophils (52, 53) and previous studies have found that highly metastatic tumor cell lines, such as 4T1 or 231, secrete more G-CSF than those with low metastatic potential, which is positively correlated with the infiltrating neutrophils, suggesting its important role in tumor metastasis (54, 55). Here, CSF3 is linked to neoplasm.