In conclusion, our case series have shown promising results in controlling and stabilizing this blinding condition, confirming the previous findings presented by Stanga et al. in terms of safety and long-term efficacy of SRF drainage, followed by anti-VEGF intravitreal injections and laser photocoagulation in stage 3 Coats disease and without SRF drainage in stage 3 Coats associated with schisis. This evidence concerns the gene VEGFA and Coats disease.