PNLIP and obesity due to melanocortin 4 receptor deficiency: According to several studies, digestive enzymes are implicated in metabolic syndrome components, namely, obesity, hypertension, hyperglycemia, hypertriglyceridemia, and hypercholesterolemia, and this metabolic imbalance is related specifically to lipolytic and metabolic enzymes such as pancreatic lipase, β-glucosidase, α-amylase, and XO [8].