According to several studies, digestive enzymes are implicated in metabolic syndrome components, namely, obesity, hypertension, hyperglycemia, hypertriglyceridemia, and hypercholesterolemia, and this metabolic imbalance is related specifically to lipolytic and metabolic enzymes such as pancreatic lipase, β-glucosidase, α-amylase, and XO [8]. The gene discussed is PNLIP; the disease is obesity disorder.