TNNI3 and cardiovascular disorder: In doing this, experimental TZM cardiotoxicity was reliably induced in the treated rats following repeated daily intraperitoneal injection of 2.25 mg/kg of TZM for 7 days as evidenced by profound elevations in the serum cardiac markers (cTnI and LDH), alterations in the serum lipids profile and cardiovascular disease risk indices, and marked alteration in the oxidative stress markers.