The first 10 items are as follows: AGE-RAGE signaling pathway in diabetic complications (hsa04933), HIF-1 signaling pathway (hsa04066), fluid shear stress and atherosclerosis (hsa05418), insulin resistance (hsa04931), PI3K-Akt signaling pathway (hsa04151), influenza A (hsa05164), EGFR tyrosine kinase inhibitor resistance (hsa01521), Kaposi sarcoma-associated herpesvirus infection (hsa05167), rheumatoid arthritis (hsa05323), and Epstein–Barr virus infection (hsa05169). The gene discussed is INS; the disease is rheumatoid arthritis.