Candidate target genes were significantly enriched in advanced glycation end products- (AGE-) receptor for the AGE (RAGE) signaling pathway in diabetic complications, fluid shear stress and atherosclerosis, hepatitis B, interleukin- (IL-) 17 signaling pathway, tumor necrosis factor (TNF) signaling pathway, Kaposi sarcoma-associated herpesvirus infection, bladder cancer, prostate cancer, endocrine resistance, pancreatic cancer, and so on (Supplementary file 6D). Here, TNF is linked to familial pancreatic carcinoma.