The main pathways included the AGE-RAGE signaling pathway in diabetic complications, fluid shear stress and atherosclerosis, the IL-17 signaling pathway, TNF signaling pathway, and pathways involved in hepatitis B, Kaposi sarcoma-associated herpes virus infection, bladder cancer, prostate cancer, endocrine resistance, and pancreatic cancer. The gene discussed is TNF; the disease is urinary bladder cancer.