APP and major depressive disorder: A recent study has found that electroacupuncture at the Baihui (DU20) acupoint shows neuroprotective effects via inhibiting the apoptosis of nerve cells, decreasing the abnormally level of β-amyloid-42, and increasing BDNF expression in APP/PS1 transgenic mice [37]; acupunctureat the Sanyinjiao (SP6) has a role in painless childbirth, in the treatment of urinary and reproductive disorders, and as anesthesia during pelvic surgery [38]; the HT7 (Shenmen) acupuncture point can ameliorate mental disorders, such as depression, anxiety, and drug addiction [39].