IL6, TNF, IL1B, TLR4, and NOS3 are related to the HIF-1 signal pathway, fluid shear stress and atherosclerosis, IL-17 signal pathway, and inflammatory mediator regulation of TRP channels, which are called inflammatory factors as effect for enhancing the level of inflammatory reaction in cerebral ischemic [31–33]. This evidence concerns the gene NOS3 and atherosclerosis.