There were 13 terms of signal pathway of AT against IS by KEGG enrichment analysis, which were ordered as ascending tendency according to P-value(P < 0.05) and contained fluid shear stress and atherosclerosis, HIF-1 signaling pathway, IL-17 signaling pathway, arachidonic acid metabolism, platelet activation, bladder cancer, inflammatory mediator regulation of TRP channels, transcriptional misregulation in cancer, PPAR signaling pathway, complement and coagulation cascades, GnRH signaling pathway, regulation of lipolysis in adipocytes, and serotonergic synapse (Figure 6). The gene discussed is HIF1A; the disease is urinary bladder cancer.