Through a sequence of phosphorylation events in the MAPK (RAS/RAF/MEK/ERK) and PI3K/Akt/mTOR pathways, downstream signaling may activate transcription factors, which modify the expression of proteins involved in important cellular processes, such as proliferation, differentiation, apoptosis, cell cycle progression, tumorigenesis, tumor growth, and angiogenesis [13, 14]. This evidence concerns the gene MAPK1 and neoplasm.