However, excessive production of IL-22 has been also associated with severe complications in several pathogen infections (12), including the recently identified Sars-Cov2 (18) as well as with inflammatory bowel diseases such as Crohn’s disease (23), neurological disorders such as MS and Guillain-Barrè syndrome (25, 26), and rheumatoid arthritis (53, 54). This evidence concerns the gene IL22 and Crohn disease.