We found that Treg cells preferentially regulate cellular signatures during chronic liver inflammation, such as Th2 cells and Ly-6Chigh CCR2high inflammatory monocytes/macrophages, which were previously reported to produce the pro-fibrotic mediators IL-4 and TGF-β, respectively (28, 36, 37) and may be regulated by Treg-derived IL-10 (38). This evidence concerns the gene TGFB1 and Hepatitis.