A wide range of different molecular tags have been exploited for this purpose in vivo, including for example, the interaction of nanocarrier borne transferrin with the transferrin receptor TfR-1 on GBM cells (228), the EGFP-EGF1 fusion protein on nanoparticles with tissue factor in tumor cells (229), and cholera toxin with tumor-expressed chloride channels and matrix metalloproteinase-2 (230). This evidence concerns the gene MMP2 and neoplasm.